Spectrally-Selective IR Diffusion-Weighted Imaging with SSFP of Bone Marrow at 3T
نویسندگان
چکیده
Introduction The use of diffusion-weighted (DW) imaging with steady-state free precession (SSFP) for the diagnosis of bone marrow has been reported (1-2). One notable limitation of this approach is the contribution of fat (lipid) signal intensity within bone marrow to the DW signal (3, 4). Healthy bone marrow contains substantial amounts of lipids (20-70%). The lipid component is reduced in pathological conditions such as malignant tumor infiltration, but lipid signal still significantly contributes to the overall DW signal. In this study we developed a novel technique for fat-suppressed DW-SSFP imaging technique based on the spectrally selective inversion pulse to null the in-plane lipid signal before data acquisition. The sequence was evaluated in terms of the degree of fat supression in phantom and healthy volunteer studies.
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